Beyond: collapsible tools and gestures for computational design

Since the invention of the personal computer, digital media has remained separate from the physical world, blocked by a rigid screen. In this paper, we present Beyond, an interface for 3-D design where users can directly manipulate digital media with physically retractable tools and hand gestures. When pushed onto the screen, these tools physically collapse and project themselves onto the screen, letting users perceive as if they were inserting the tools into the digital space beyond the screen. The aim of Beyond is to make the digital 3-D design process straightforward, and more accessible to general users by extending physical affordances to the digital space beyond the computer screen

Mid-Air tangible interaction enabled by computer controlled magnetic levitation

Thesis (S.M.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2011.Cataloged from PDF version of thesis.Includes bibliographical references (p. 83-86).This thesis presents a concept of mid-air tangible interaction and a system called ZeroN that was developed to enable this interaction. Through this research, I extend the tabletop tangible interaction modalities which have been confined to 2D surfaces into 3D space above the surface. Users are invited to place and move a levitated object in the mid-air space, which is analogous to placing objects on 2D surfaces. For example, users can place a physical object that represents the sun above physical objects to cast digital shadows, or place a planet that will start revolving based on simulated physical conditions. To achieve these interaction scenarios, we developed ZeroN, a new tangible interface element that can be levitated and moved freely by computer in a three dimensional space. In doing so, ZeroN serves as a tangible representation of a 3D coordinate of the virtual world through which users can see, feel, and control computation. Our technological development includes a magnetic and mechanical control system that can levitate and actuate a permanent magnet in 3D space. This is combined with an optical tracking and display system that projects images on the levitating object. In this thesis, I present interaction techniques and applications developed in the context of this system. Finally, I discuss initial observations and implications, and outline future development and challenges.by Jinha Lee.S.M

SpaceTop: integrating 2D and spatial 3D interactions in a see-through desktop environment

SpaceTop is a concept that fuses spatial 2D and 3D interactions in a single workspace. It extends the traditional desktop interface with interaction technology and visualization techniques that enable seamless transitions between 2D and 3D manipulations. SpaceTop allows users to type, click, draw in 2D, and directly manipulate interface elements that float in the 3D space above the keyboard. It makes it possible to easily switch from one modality to another, or to simultaneously use two modalities with different hands. We introduce hardware and software configurations for co-locating these various interaction modalities in a unified workspace using depth cameras and a transparent display. We describe new interaction and visualization techniques that allow users to interact with 2D elements floating in 3D space. We present the results from a preliminary user study that indicates the benefit of such hybrid workspaces

Effects of time perspective and self-control on procrastination and Internet addiction

College students experiencing stress show tendencies to procrastinate and can develop Internet addiction problems. This study investigated the structural relationship between time perspective and self-control on procrastination and Internet addiction. Methods College students (N = 377) residing in South Korea completed the following questionnaires: the Pathological Internet Use Behavior Symptom Scale for Adults, the Zimbardo Time Perspective Inventory, the Self-Control Rating Scale, and the Aitken Procrastination Inventory. The sample variance–covariance matrix was analyzed using AMOS 20.0. Results Time perspective had a direct effect on self-control and an indirect effect on Internet use and procrastination. In addition, self-control affected procrastination and Internet use. Conclusions Individuals with a present-oriented time perspective tend to evidence poorer self-control, increasing the likelihood of procrastination and Internet addiction. Individuals with a future-oriented time perspective, on the other hand, tend to have stronger self-control, decreasing their risk of procrastination and Internet addiction

Geospatial Clustering Analysis on Drug Abuse Emergencies

The epidemic of drug abuse is a serious public health issue in the U.S. The number of overdose deaths involving prescription opioids and illicit drugs has continuously increased over the last few years. This study aims to develop a geospatial model that identifies geospatial clusters in terms of socioeconomic and demographic characteristics with an unsupervised machine learning algorithm. Then, we suggest the most important features affecting heroin overdose both negatively and positively. The findings of this study may inform policymakers about strategies to mitigate the drug overdose crisis

Geospatial Clustering Analysis on Drug Abuse Emergencies

The epidemic of drug abuse is a serious public health issue in the U.S. The number of overdose deaths involving prescription opioids and illicit drugs has continuously increased over the last few years. This study aims to develop a geospatial model that identifies geospatial clusters in terms of socioeconomic and demographic characteristics with an unsupervised machine learning algorithm. Then, we suggest the most important features affecting heroin overdose both negatively and positively. The findings of this study may inform policymakers about strategies to mitigate the drug overdose crisis

Spatial clustering of heroin-related overdose incidents: a case study in Cincinnati, Ohio

Drug overdose is one of the top leading causes of accidental death in the U.S., largely due to the opioid epidemic. Although the opioid epidemic is a nationwide issue, it has not affected the nation uniformly

Sublimate: State-Changing Virtual and Physical Rendering to Augment Interaction with Shape Displays

Recent research in 3D user interfaces pushes towards immersive graphics and actuated shape displays. Our work explores the hybrid of these directions, and we introduce sublimation and deposition, as metaphors for the transitions between physical and virtual states. We discuss how digital models, handles and controls can be interacted with as virtual 3D graphics or dynamic physical shapes, and how user interfaces can rapidly and fluidly switch between those representations. To explore this space, we developed two systems that integrate actuated shape displays and augmented reality (AR) for co-located physical shapes and 3D graphics. Our spatial optical see-through display provides a single user with head-tracked stereoscopic augmentation, whereas our handheld devices enable multi-user interaction through video seethrough AR. We describe interaction techniques and applications that explore 3D interaction for these new modalities. We conclude by discussing the results from a user study that show how freehand interaction with physical shape displays and co-located graphics can outperform wand-based interaction with virtual 3D graphics.National Science Foundation (U.S.) (Graduate Research Fellowship Grant 1122374

Molecular Evolution Patterns in Metastatic Lymph Nodes Reflect the Differential Treatment Response of Advanced Primary Lung Cancer

Tumor heterogeneity influences the clinical outcome of patients with cancer, and the diagnostic method to measure the tumor heterogeneity needs to be developed. We analyzed genomic features on pairs of primary and multiple metastatic lymph nodes from six patients with lung cancer using whole-exome sequencing and RNA sequencing. Although somatic single-nucleotide variants were shared in primary lung cancer and metastases, tumor evolution predicted by the pattern of genomic alterations was matched to anatomic location of the tumors. Four of six cases exhibited a branched clonal evolution pattern. Lymph nodes with acquired somatic variants demonstrated resistance to the cancer treatment. In this study, we demonstrated that multiple biopsies and sequencing strategies for different tumor regions are required for a comprehensive understanding of the landscape of genetic alteration and for guiding targeted therapy in advanced primary lung cancer. Cancer Res; 76(22); 6568-76. ©2016 AACR

Population pharmacokinetics of everolimus in patients with seizures associated with focal cortical dysplasia

Background: Everolimus is an inhibitor of mammalian target of rapamycin complex 1. As mutations in TSC1 and TSC2, which cause partial-onset seizures associated with TSC, were found in focal cortical dysplasia type Ⅱ (FCD Ⅱ) patients, a clinical trial has been performed to explore the efficacy and safety of everolimus in FCD patients. However, no dosage regimen was determined to treat FCD II. To recommend an optimal dose regimen for FCD patients, a population pharmacokinetic model of everolimus in FCD patients was developed.Methods: The data of everolimus were collected from September 2017 to May 2020 in a tertiary-level hospital in Korea. The model was developed using NONMEM® software version 7.4.1 (Icon Development Solutions, Ellicott City, MD, United States).Results: The population pharmacokinetics of everolimus was described as the one-compartment model with first-order absorption, with the effect of BSA on clearance. The final model was built as follows: TVCL = 12.5 + 9.71 × (BSA/1.5), TVV = 293, and TVKA = 0.585. As a result of simulation, a dose higher than 7 mg/m2 is needed in patients with BSA 0.5 m2, and a dose higher than 6 mg/m2 is needed in patients with BSA 0.7 m2. A dose of 4.5 mg/m2 is enough in the population with BSA higher than 1.5 m2 to meet the target trough range of 5–15 ng/mL.Conclusion: Based on the developed pharmacokinetics model, the optimal dose of everolimus in practice was recommended by considering the available strengths of Afinitor disperz®, 2 mg, 3 mg, and 5 mg